Evidence for impaired glucose metabolism in the striatum, obtained postmortem, from some subjects with schizophrenia

B Dean; N Thomas; E Scarr; M Udawela

Journal article

Evidence for impaired glucose metabolism in the striatum, obtained postmortem, from some subjects with schizophrenia

B Dean, N Thomas, E Scarr, M Udawela

Translational Psychiatry | NATURE PUBLISHING GROUP | Published : 2016

DOI: 10.1038/TP.2016.226

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Abstract

Studies using central nervous system tissue obtained postmortem suggest pathways involved in energy and metabolism contribute to the pathophysiology of schizophrenia; neuroimaging studies suggesting glucose metabolism is particularly affected in the striatum. To gain information on the status of pathways involved in glucose metabolism in the striatum, we measured levels of glucose, pyruvate, acetyl-CoA and lactate as well as the β subunit of pyruvate dehydrogenase, a rate limiting enzyme, in the postmortem tissue from subjects with schizophrenia and age/sex-matched controls. The subjects with schizophrenia were made up of two subgroups, which could be divided because they either had (muscari..

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University of Melbourne Researchers

Brian Dean Author Florey Department of Neuroscience and Mental Health

Natalie Thomas Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

We thank Geoffrey Pavey for dissecting the tissue used in this study. This research was funded in part by NHMRC Project Grant APP1045619 and the Victorian Government's Operational Infrastructure Support. BD is the recipient of an NHMRC Fellowship (APP1002240). NT was the recipient of a PhD scholarship from the Rebecca Cooper Medical research Foundation. The Victorian Brain Bank Network is supported by the Florey Institute for Neuroscience and Mental Health, the Alfred Hospital, the Victorian Forensic Institute of Medicine, the University of Melbourne and funded by Australia's National Health & Medical Research Council, Helen Macpherson Smith Trust, Parkinson's Victoria and Perpetual Philanthropic Services.